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NAPLEX Practice Exam Questions and Answers

North American Pharmacist Licensure Examination

Last Update 5 days ago
Total Questions : 154

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Question # 1

Which of these drugs is used to prevent contrast-induced nephropathy?

Options:

A.  

Metformin

B.  

Activated charcoal

C.  

N-acetylcysteine

D.  

Spironolactone

E.  

Mannitol

Discussion 0
Question # 2

A physician orders 300gms of albumin post paracentesis, how many milliliters of 25% albumin do you need to give 300gms?

Options:

A.  

300ml

B.  

25ml

C.  

100ml

D.  

1200ml

E.  

1000ml

Discussion 0
Question # 3

A CD4 count of 180 cells per cubic meter may be evaluated as which of these?

Options:

A.  

Very low

B.  

Low

C.  

High

D.  

Severely high

Discussion 0
Question # 4

The rate that an outcome will occur given a particular exposure, compared to the rate of the outcome occurring in the absence of that exposure is definition of which of the following?

Options:

A.  

Incidence rate

B.  

Prevelance rate

C.  

Odds ratio

D.  

Relative risk

E.  

Confidence Interval

Discussion 0
Question # 5

Which of the following Anti-epileptic medication can cause pancreatitis?

Options:

A.  

Carbamazepine

B.  

Gabapentin

C.  

Valproic acid

D.  

Levetiracetam

E.  

Phenobarbital

Discussion 0
Question # 6

A patient with acute pharyngitis caused by group A Streptococcus (strep throat) is allergic to penicillins (non- immediate type), which of the following is NOT recommended as treatment?

Options:

A.  

Clindamycin

B.  

Amoxicillin

C.  

Cefalexin

D.  

Clarithromycin

Discussion 0
Question # 7

The administration of dapsone gel for the topical treatment of acne vulgaris in patients with G6PD deficiency may produce which of these?

Options:

A.  

Anaphylaxis

B.  

Fungal infections

C.  

Hemolysis

D.  

Immunosuppression

Discussion 0
Question # 8

Select the class of Anti-diabetic medication that works in the specified organto prevent hyperglycemia. Select all that applies. Fat Tissue (H)

Options:

A.  

Sulfonylureas

B.  

Alpha- Glucosidase Inhibitors

C.  

DPP4 Inhibitors

D.  

Glucagon-like peptide-1 receptor agonists

E.  

Thiazolidinediones

F.  

Biguanide

G.  

SGLT2 inhibitors

Discussion 0
Question # 9

What is the Osmolarity in mOsm/L of 40mEq of KCl in 100ml sterile water? (Molecular weight of KCl is 74.5gm/ mol.)?

Options:

A.  

400mOsm/L

B.  

800mOsm/L

C.  

80mOsm/L

D.  

200mOsm/L

E.  

1600mOsm/L

Discussion 0
Question # 10

A patient with multibacillary leprosy is on dapsone, clofazimine, and rifampin. Which of the following is true regarding the mechanism of action of the medications listed?

Options:

A.  

Dapsone is bacteriostatic because of its inhibitory effects on dihydrofolate reductase

B.  

Dapsone is bacteriostatic because of its inhibitory effects on myeloperoxidase

C.  

Clofazimine is bactericidal by directly inhibiting bacterial DNA polymerase

D.  

Rifampin is bacteriostatic by inhibiting RNA synthesis by blocking DNA-dependent RNA polymerase

E.  

Rifampin is bactericidal by inhibiting RNA synthesis by blocking DNA-dependent RNA polymerase

Discussion 0
Question # 11

Which of the following medication should be avoided if a patient is on lithium to avoid lithium toxicity?

Options:

A.  

Lisinopril

B.  

Furosemide

C.  

Naproxen

D.  

Amiodarone

E.  

Warfarin

Discussion 0
Question # 12

Which of the following statements is true regarding Drug-receptor bonds?

Options:

A.  

Covalent bonds of drugs with receptors are strong and mostly reversible

B.  

Covalent bonding is much more common than electrostatic bonding in drug-receptor interactions

C.  

Electrostatic bonds are stronger than covalent bonds

D.  

Hydrophobic bonds are weak bonds and they are important in the interactions of highly water soluble drugs with the lipids of cell membranes

E.  

Bond formation of between the acetyl group of aspirin and cyclo-oxygenase enzyme is a covalent bond

Discussion 0
Question # 13

You need 51.3 mEq of NaCl to make 1/3 NS 1 liter bag. How many ml of 23.4% NaCl would you need? (Molecular weight of Na is 23 and Cl is 35.5)

Options:

A.  

12.82ml

B.  

16.82ml

B.  

23.4ml

C.  

58.5ml

D.  

10ml

Discussion 0
Question # 14

When does the newer chronic kidney disease (CKD) guidelines recommend stopping metformin?

Options:

A.  

when the estimated glomerular filtration (eGFR) is <30 mL/min/1.73 m2

B.  

when estimated glomerular filtration (eGFR) is <50 mL/min/1.73 m2

C.  

when creatinine clearance <30 ml/min

D.  

when creatinine clearance <50 ml/min

E.  

when serum creatinine is <1.8 mg/dL

Discussion 0
Question # 15

A 20-year-old student came to the emergency department with primary complaints of palpitations, low-grade fever, and anxiety for 2 months. She reports that she is irritable and suffers severe mood swings that is interfering with her sleep and relationships (she admits to crying spells and frequent fights with friends and family). She has also lost 12 pounds in the past 2 months with no apparent alteration in her diet or physical activity (though she is happy with her weight loss). She denies any past medical problems, though her friends have always been worried that she eats too little.

Her temperature is 38.0 C (100.4 F), blood pressure is 148/62 mm Hg, pulse is 122/min and regular, and respiratory rate is 28/min. Examination reveals a bruit heard over the anterior neck, fine tremor of the hands, and warm, moist skin. Her eyes and eyelids do not move together during finger following test (with steady head). Laboratory work is sent, including a thyroid panel, but will not be available until tomorrow morning.

Which of the following is the most appropriate initial management at this time?

Options:

A.  

Diltiazem therapy

B.  

Iodine therapy

C.  

Methimazole therapy

D.  

Propranolol therapy

E.  

Referral to a surgeon

Discussion 0
Question # 16

Which of the following are complication associated with long term use of proton pump inhibitors?

Options:

A.  

Bone fractures

B.  

Hypomagnesemia

C.  

Vitamin B12 deficiency

D.  

Clostridium difficile infection

E.  

Helicobacter pylori infection

Discussion 0
Question # 17

Which of these cardiovascular drug classes is most associated with tachyphylaxis?

Options:

A.  

ACE inhibitors

B.  

Angiotensin-receptor blockers

C.  

Direct renin inhibitors

D.  

Calcium channel blockers

E.  

Nitrates

Discussion 0
Question # 18

Which of the following illnesses is an example of a type III hypersensitivity reaction?

Options:

A.  

Lupus

B.  

Graves disease

C.  

Hashiomoto’s thyroiditis

D.  

Allergic rhinitis

E.  

Myasthenia gravis

Discussion 0
Question # 19

Results from a Meta-analysis where they looked at frequency of postoperative arterial fibrillation in patients on Ascorbic acid after cardiac surgery found odds ratio, 0.44 (95% CI, 0.32 to 0.61). How can you interpret this data?

Options:

A.  

Ascorbic acid increased frequency of postoperative arterial fibrillation after cardiac surgery by 44%

B.  

Ascorbic acid decreased frequency of postoperative arterial fibrillation after cardiac surgery by 44%

C.  

There was no statistically significant difference in frequency of postoperative arterial fibrillation after cardiac surgery

D.  

Ascorbic acid decreased frequency of postoperative arterial fibrillation after cardiac surgery by 56%

E.  

None of the above are correct

Discussion 0
Question # 20

MT is 47-year-old man who presents to the ER with painful, red, swollen area on his left leg. His temperature is 38.4, respiratory rate 30 and heart rate 95. He has been taking cephalexin day 4 today, as prescribed by his primary care physician. His CMP is normal a CBC shows elevated WBC of 16,000/mm3.

What would be the most appropriate antibiotic/s to initiate on MT empirically?

Options:

A.  

Vancomycin IV and Piperacillin/Tazobactam

B.  

IV Doxycycline and Ceftazidime

C.  

Nafcillin

D.  

Vancomycin IV.

E.  

Ceftriaxone

Discussion 0
Question # 21

Which of the following would be most appropriate to treat infections associated with stenotrophomonas maltophilia?

Options:

A.  

Meropenem

B.  

Vancomycin

C.  

Ciprofloxacin

D.  

Sulfamethoxazole/trimethoprim

E.  

Ampicillin

Discussion 0
Question # 22

JM is a 32-year-old women who comes to your diabetic clinic with complain of several episodes of hypoglycemia. She is on Insulin NPH/regular 70/30, 22 units twice a day with breakfast and dinner. 8 units with lunch.

After discussing with physician you decide to decrease the total daily insulin by 10% and change to insulin glargine once a day and Insulin Lispro three time a day at ratio of 50:50 – 50 % of long and 50 % of short acting insulin.

What is her new insulin regimen? Round down to the nearest 1 unit.

Options:

A.  

16 units of insulin glargine once daily, Insulin Lispro 4 units 3 times a day with meals

B.  

15 units of insulin glargine once daily, Insulin Lispro 5 units 3 times a day with meals

C.  

23 units of insulin glargine once daily, Insulin Lispro 7 units 3 times a day with meals

D.  

30 units of insulin glargine once daily, Insulin Lispro 6 units 3 times a day with meals

E.  

18 units of insulin glargine once daily, Insulin Lispro 6 units 3 times a day with meals

Discussion 0
Question # 23

Which of the following is/are nominal data?

Options:

A.  

Sex

B.  

Race

C.  

Blood Group

D.  

NYHA stages I-IV

E.  

Stages of breast cancer

Discussion 0
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